`V'(O_2) = ( "V'I" * "FIO_2" )-( "V'E" * "FEO_2" )`

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The oxygen uptake (VO₂) of an person is the amount of oxygen which the body uses in a minute per kilogram of the body's weight. It's the most relevant measure of the cardiorespiratory system. It is also the highest rate at which oxygen can be consumed is called VO2Max, distributed and used by the body during exercise. It is determined relative to body weight as millimeters of oxygen per kilogram of body weight.

      
 V’O₂ = (V’I)(FIO₂) – (V’E)(FEO₂) 

• FIO₂ = [O₂] in inspired air
• V’E = expired minute ventilation
• FEO2 = [O2] in expired air
• V’O2 = oxygen uptake/min
• V’I = inspired minute ventilation

Notes

Oxygen consumption is the amount of oxygen taken up and utilized by the body.  The oxygen taken into the body at the level of the lungs is ultimately used for the production of ATP in the mitochondria of our cells.  Because most of the energy in the body is produced aerobically, VO2 can be used to determine how much energy a subject is expending.  VO2 can be reported in absolute terms (L/min) or relative to body mass (ml/kg*min).  Oxygen consumption is dependent on the ability of the heart to pump out blood, the ability of the tissues to extract oxygen from the blood, the ability to ventilate and the ability of the alveoli to extract oxygen from the air.